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Silicified Microcrystalline Cellulose : PROSOLV® JRS RETTENMAIER France

Silicified Microcrystalline Cellulose : PROSOLV®

Special chemistry

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Excipients that meet the following criteria are considered high functionality excipients (HFEs):

  1. Multi-functionality, contributing two or more functions to a formulation through a single ingredient.
  2. High inherent functional performance, allowing larger batch sizes and higher drug loading even at low use levels.
  3. No complex processing, making them ideal for cost-effective direct compression processes.
  4. High inherent functional performance that encompasses the overall formulation, unlike other multi-functional excipients or conventional specialty-grade excipients.

High Functionality Excipients simplify formulation development and improve overall operational costs while preserving the quality expected by the industry.

Our innovative high functionality excipient line includes:

  • PROSOLV® SMCC
  • PROSOLV® EASYtab SP
  • PROSOLV® ODT G2
  • PROSOLV® EASYtab Nutra


PROSOLV® SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD). A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation.

PROSOLV® SMCC is unique in that it imparts both optimum compaction and superior flow to formulations. It also exhibits both brittle fracture and plastic deformation characteristics, leading to superior binding properties. The production process of PROSOLV® SMCC leads to homogenous and much finer CSD particle size distribution. This results in a five-fold specific surface area increase, as well as in a 30-50% compaction increase compared to traditional MCC. The increased surface area enables superior flow and increased compaction and results in improved content uniformity and stability in the formulation.

When used for direct compression, PROSOLV® SMCC can replace granulations, while significantly reducing the number of required excipients and use levels. PROSOLV® SMCC formulations produce distinctive, uniform, and cost effective tablets.

PROSOLV® SMCC is available in a number of different grades.

PROSOLV® SMCC offers:

  • Excellent compactibility
  • High intrinsic flow
  • Enhanced lubrication efficiency
  • Improved blending properties
  • Superior binding properties
  • Increased production capacity


PROSOLV® EASYtab SP is an all-in-one, ready-to-use, homogenous lubricant-coated high functionality excipient composite. It is comprised of four individual components: a binder-filler, a glidant, a superdisintegrant, and a lubricant. These components maintain their chemical identities while synergistically providing increased functional performance.

All-in-One Composite: Binder-filler, Glidant, Superdisintegrant, and Lubricant
Microcrystalline Cellulose, Colloidal Silicon Dioxide, Sodium Starch Glycolate, Sodium Stearyl Fumarate 

PROSOLV® EASYtab SP tablets are robust, offer good API stability, and require lower excipient levels than traditional blends. The advantage of using PROSOLV® EASYtab SP is higher profitability through economic savings due to higher productivity, lower set-up and cleaning costs, higher yield, and less loss.

With PROSOLV® EASYtab SP, buy and store one product instead of four, saving on equipment capital, inventory, and analysis costs.

PROSOLV® EASYtab SP offers:

  • Good flowability
  • Less sticking
  • Excellent content uniformity
  • Good hardness
  • Low friability
  • High intrinsic flow
  • Excellent film adhesion
  • Improved embossing properties
  • Improved content uniformity of low-dose drugs
  • Total cost savings 


PROSOLV® EASYtab Nutra is a high functionality pre-lubricated excipient (inactive ingredient) composite made specifically for direct compression nutraceutical applications.

All-in-One, Ready-to-Use Excipient Composite: Binder, Glidant, Superdisintegrant, Lubricant
Microcrystalline Cellulose, Colloidal Silicon Dioxide, Croscarmellose, Palm Kernel Oil saturated, DATEM 

PROSOLV® EASYtab Nutra is an all-in-one excipient composite composed of four components: binder, glidant, disintegrant, and lubricant. All ingredients conform to the requirements of the nutraceutical industry. With PROSOLV® EASYtab Nutra, formulators can simplify the production of nutritional tablets while still producing robust formulations. Simply add PROSOLV® EASYtab Nutra to the active ingredients, blend, and compress into tablets.

All components of PROSOLV® EASYtab Nutra are co-processed, maintaining each ingredient's chemical identity while synergistically providing increased functional performance even with complex formulations. This leads to significant savings in production costs compared to other techniques such as wet granulation or encapsulation.

PROSOLV® EASYtab Nutra allows faster time-to-market through shorter development times and easier inventory control with the purchase of one ingredient instead of four.

PROSOLV® EASYtab Nutra offers:

  • Good flowability
  • Less sticking
  • Excellent content uniformity
  • Good hardness
  • Low friability
  • High intrinsic flow
  • Excellent film adhesion
  • Improved embossing properties
  • Improved content uniformity of low-dose drugs
  • Total cost savings 



PROSOLV® ODT G2 is a high functionality excipient for orally disintegrating tablet formulation, development, and manufacture. This innovative orally disintegrating tablet (ODT) matrix is a unique combination of soluble and insoluble ingredients manufactured using JRS Pharma's co-processing technology.

Orally Disintegrating Tablet Excipient Matrix
Microcrystalline Cellulose, Colloidal Silicon Dioxide, Mannitol, Fructose, Crospovidone                          

It provides a pleasing, convenient, and discreet form of administration for active pharmaceutical and nutritional ingredients without the need for water. PROSOLV® ODT G2 offers the functional performance needed for today's orally disintegrating tablet formulation challenges and complies with globally accepted and monographed raw materials.

PROSOLV® ODT G2 addresses formulation and manufacturing challenges with a robust functional performance that high-speed tablet manufacturing requires. Patients experience tablets with pleasing mouth-feel and fast disintegration in the oral cavity, with no need for water.

PROSOLV® ODT G2 offers:

  • Smooth and creamy mouthfeel
  • Excellent flowability
  • Superior compaction profile when compared to other matrices
  • Excellent blending characteristics for improved content uniformity
  • High patient compliance 

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